A coarse-grained computational model of the nuclear pore complex predicts Phe-Gly nucleoporin dynamics

@article{Pulupa2017ACC,
  title={A coarse-grained computational model of the nuclear pore complex predicts Phe-Gly nucleoporin dynamics},
  author={Joan Pulupa and Manas Rachh and Michael D. Tomasini and Joshua S. Mincer and Sanford M. Simon},
  journal={The Journal of General Physiology},
  year={2017},
  volume={149},
  pages={951 - 966}
}
The phenylalanine-glycine–repeat nucleoporins (FG-Nups), which occupy the lumen of the nuclear pore complex (NPC), are critical for transport between the nucleus and cytosol. Although NPCs differ in composition across species, they are largely conserved in organization and function. Transport through the pore is on the millisecond timescale. Here, to explore the dynamics of nucleoporins on this timescale, we use coarse-grained computational simulations. These simulations generate predictions… 
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