A coalescent simulation of marker selection strategy for candidate gene association studies.

@article{Cole2008ACS,
  title={A coalescent simulation of marker selection strategy for candidate gene association studies.},
  author={Suzanne M Cole and Jeffrey C. Long},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2008},
  volume={147B 1},
  pages={86-93}
}
Recent efforts have focused on the challenges of finding alleles that contribute to health-related phenotypes in genome-wide association studies. However, in candidate gene studies, where the genomic region of interest is small and recombination is limited, factors that affect the ability to detect disease-susceptibility alleles remain poorly understood. In particular, it is unclear how varying the number of markers on a haplotype, the type of marker (e.g., single nucleotide polymorphism (SNP… CONTINUE READING

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