A coalescent model of background selection with recombination, demography and variation in selection coefficients

@article{Zeng2013ACM,
  title={A coalescent model of background selection with recombination, demography and variation in selection coefficients},
  author={Kai Zeng},
  journal={Heredity},
  year={2013},
  volume={110},
  pages={363-371}
}
There is increasing evidence that background selection, the effects of the elimination of recurring deleterious mutations by natural selection on variability at linked sites, may be a major factor shaping genome-wide patterns of genetic diversity. To accurately quantify the importance of background selection, it is vital to have computationally efficient models that include essential biological features. To this end, a structured coalescent procedure is used to construct a model of background… CONTINUE READING

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The structure of genealogies in the presence of purifying selection : a fitnessclass coalescent

  • GA Watterson
  • Genetics
  • 2012

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