A co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae.

  title={A co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae.},
  author={S Soussi-Boudekou and Bruno Andr{\'e}},
  journal={Molecular microbiology},
  volume={31 3},
In Saccharomyces cerevisiae, the transcription factors Gln3p and Nil1p of the GATA family play a determinant role in expression of genes that are subject to nitrogen catabolite repression. Here we report the isolation of a new yeast mutant, gan1-1, exhibiting dramatically decreased NAD-linked glutamate dehydrogenase (NAD-GDH) and glutamine synthetase (GS) activities. The GAN1 gene was cloned and found to encode a 488-amino-acid polypeptide bearing no typical DNA binding domain. Gan1p is… CONTINUE READING


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