A cluster of novel serotonin receptor 3-like genes on human chromosome 3.

@article{Karnovsky2003ACO,
  title={A cluster of novel serotonin receptor 3-like genes on human chromosome 3.},
  author={Alla M Karnovsky and Lisa F. Gotow and Denise D. McKinley and Julie L. Piechan and Cara L A Ruble and Cynthia J. Mills and Kathleen A.B. Schellin and Jerry Laverne Slightom and Laura R. Fitzgerald and Christopher W. Benjamin and Steven L. Roberds},
  journal={Gene},
  year={2003},
  volume={319},
  pages={
          137-48
        }
}
The ligand-gated ion channel family includes receptors for serotonin (5-hydroxytryptamine, 5-HT), acetylcholine, GABA, and glutamate. Drugs targeting subtypes of these receptors have proven useful for the treatment of various neuropsychiatric and neurological disorders. To identify new ligand-gated ion channels as potential therapeutic targets, drafts of human genome sequence were interrogated. Portions of four novel genes homologous to 5-HT(3A) and 5-HT(3B) receptors were identified within… CONTINUE READING
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