A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.

  title={A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.},
  author={C. M. Olarte-S{\'a}nchez and L Valencia Torres and Stephanie Body and Helen Joan Cassaday and Christopher M. Bradshaw and Elem{\'e}r Szabadi and Andrew J. Goudie},
  journal={Journal of psychopharmacology},
  volume={26 6},
The atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-HT₂) and histamine (H₁) receptor antagonist effects, are shared by the non-selective 5-HT receptor antagonist cyproheptadine. Atypical antipsychotics have a characteristic profile of action on operant behaviour maintained by progressive ratio schedules, as revealed by Killeen's (1994) mathematical model of schedule controlled behaviour. These drugs increase the values… CONTINUE READING


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