A clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipient.

@article{Maguire2012ACS,
  title={A clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipient.},
  author={Michelle Maguire and Thaddeus Franz and David S. Hains},
  journal={Pediatric transplantation},
  year={2012},
  volume={16 6},
  pages={E217-20}
}
The shared metabolism of PPIs and tacrolimus through the CYP enzyme system has been associated with clinically significant drug interactions, especially in patients who are classified as CYP 2C19 PMs. However, existing data are conflicting, indicating that a single mechanism does not account for all interactions. A drug interaction between tacrolimus and omeprazole, esomeprazole, but not lansoprazole, occurred in an 18-yr-old female kidney transplant recipient classified as a CYP 2C19 extensive… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Similar Papers

Loading similar papers…