A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials.

@article{Cui2005ACR,
  title={A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials.},
  author={Jianhua Cui and Jinsheng Li and Megumi Mathison and Fernando Tondato and Stephen P Mulkey and Connie Micko and Nicolas A F Chronos and Keith A. Robinson},
  journal={Cardiovascular revascularization medicine : including molecular interventions},
  year={2005},
  volume={6 3},
  pages={113-20}
}
Extracellular matrix (ECM) scaffolds may be useful as a tissue engineering approach toward myocardial regeneration in the infarcted heart. An appropriate large-animal model for testing the utility of biologically derived ECM in this application is needed. The purpose of this study was to develop such a model for optimal procedural success during and after patch implantation surgery. Myocardial infarction (MI) was created by embolization of the diagonal artery (DA) branch of the left anterior… CONTINUE READING