A clinically applicable method for determining the three major alleles at the Duffy (FY) blood group locus using polymerase chain reaction with allele-specific primers.

@article{Olsson1998ACA,
  title={A clinically applicable method for determining the three major alleles at the Duffy (FY) blood group locus using polymerase chain reaction with allele-specific primers.},
  author={Martin L Olsson and Caroline Hansson and Neil David Avent and I E Akesson and Caroll A Green and Geoff L Daniels},
  journal={Transfusion},
  year={1998},
  volume={38 2},
  pages={168-73}
}
BACKGROUND The clinically significant antigens of the Duffy (Fy [FY]) blood group system are expressed on the red cell form of the FY glycoprotein, a promiscuous chemokine receptor and also a receptor for malarial parasites. After the cloning of cDNA coding for FY glycoprotein, the molecular basis of the three major alleles (Fya/Fyb/Fy) has been established. Because of the mistyping of the silent Fy allele as Fyb, the error rate of current genotyping methods is high in black populations… CONTINUE READING

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