Menopausal complaints, especially hot flushes, are common occurrences. Until now, no effective treatment was available for patients in whom estrogens are contraindicated. A trial of veralipride was carried out in ten symptomatic menopausal women (7 physiologic menopauses, 3 surgical menopauses). Symptoms included severe hot flushes, anxiety (N = 6), depression (N = 4), irritability (N = 3), and cephalalgia (N = 2). Patients were given one tablet of veralipride each day for twenty day periods. Effectiveness on hot flushes was excellent in six patients, satisfactory in two, mediocre in one, and null in one. Depression, anxiety, and, to a lesser extent, cephalalgia and irritability, were alleviated. No clinical or biological adverse side-effects were recorded.