A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts

@article{Bickel1988ACT,
  title={A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts},
  author={W. Bickel and M. Stitzer and G. Bigelow and I. Liebson and D. Jasinski and R. Johnson},
  journal={Clinical Pharmacology & Therapeutics},
  year={1988},
  volume={43}
}
  • W. Bickel, M. Stitzer, +3 authors R. Johnson
  • Published 1988
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oral methadone under double‐dummy and double‐blind conditions to study the pharmacology of buprenorphine in a 90‐day detoxification protocol. The patients were administered either 2 mg buprenorphine or 30 mg methadone for 3 weeks followed by 4 weeks of dose reductions and 6 weeks of placebo medication. No… CONTINUE READING
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