A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts

  title={A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts},
  author={Warren K. Bickel and Maxine L. Stitzer and George E. Bigelow and Ira A. Liebson and Donald R. Jasinski and Rolley E. Johnson},
  journal={Clinical Pharmacology \& Therapeutics},
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oral methadone under double‐dummy and double‐blind conditions to study the pharmacology of buprenorphine in a 90‐day detoxification protocol. The patients were administered either 2 mg buprenorphine or 30 mg methadone for 3 weeks followed by 4 weeks of dose reductions and 6 weeks of placebo medication. No… 
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Patients in both medication groups showed significant and substantial improvements over time in areas of psychosocial functioning, as assessed by the Addiction Severity Index, rates of urinalysis tests positive for opioids, and self-reports of opioid withdrawal symptoms, illicit opioid use, and cocaine use.
Comparison of Buprenorphine and Methadone in the Treatment of Opiate Withdrawal: Possible Advantages of Buprenorphine for the Treatment of Opiate-Benzodiazepine Codependent Patients?
Buprenorphine detoxification was associated with less severe opiate withdrawal symptoms than methadone and opiate/Benzodiazepine codependent patients reported less severe withdrawal symptoms during treatment with buprenorphines than with methad one.
Comparative Safety and Side Effect Profiles of Buprenorphine and Methadone in the Outpatient Treatment of Opioid Dependence
There is no evidence that buprenorphine is selectively associated with abnormal liver function compared with methadone, and there are few clinically significant gender differences in the comparative safety and side effect profiles.
Use of buprenorphine in the treatment of opiate addiction. I. Physiologic and behavioral effects during a rapid dose induction
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Buprenorphine suppresses heroin use by heroin addicts.
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Electroencephalographic and behavioral correlates of buprenorphine administration
It is concluded that, consistent with its classification as a partial opiate agonist, buprenorphine may not substitute fully for methadone.
Buprenorphine effects on human heroin self-administration: an operant analysis.
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