A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts

@article{Bickel1988ACT,
  title={A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts},
  author={Warren K. Bickel and Maxine L. Stitzer and George E. Bigelow and Ira A. Liebson and Donald R. Jasinski and Rolley E. Johnson},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1988},
  volume={43}
}
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oral methadone under double‐dummy and double‐blind conditions to study the pharmacology of buprenorphine in a 90‐day detoxification protocol. The patients were administered either 2 mg buprenorphine or 30 mg methadone for 3 weeks followed by 4 weeks of dose reductions and 6 weeks of placebo medication. No… 
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References

SHOWING 1-9 OF 9 REFERENCES
Buprenorphine suppresses heroin use by heroin addicts.
TLDR
Buprenorphine should be a safe and effective new pharmacotherapy for heroin dependence and indicated that it was preferable to methadone or naltrexone.
Electroencephalographic and behavioral correlates of buprenorphine administration
TLDR
It is concluded that, consistent with its classification as a partial opiate agonist, buprenorphine may not substitute fully for methadone.
Buprenorphine effects on human heroin self-administration: an operant analysis.
The use of the Polaroid close - up camera in pupillography
  • 1967
Drugs for heroin detoxification 77
    cology and abuse potential of the analgesic buprenorphine
    • Arch Gen Psychiatry
    • 1978