A clinical safety trial of stroma-free hemoglobin.

  title={A clinical safety trial of stroma-free hemoglobin.},
  author={J P Savitsky and J Doczi and James Black and John D. Arnold},
  journal={Clinical pharmacology and therapeutics},
  volume={23 1},
A stroma-free hemoglobin (SFH) solution was prepared which was sterile, pyrogen free, and contained only 1.2% of the stromal lipid present in unpurified hemolysate, 250 ml of which was administered slowly intravenously to 8 healthy men. Two control subjects received 250 ml of serum albumin. The SFH infusions were generally well tolerated by 7 of the 8 men. One subject developed abdominal pain and costovertebral angle tenderness after infusion, which disappeared within 48 hr. Bradycardia and a… CONTINUE READING