A clinical patho‐anatomical study of clinically silent multiple sclerosis

@article{Engell1989ACP,
  title={A clinical patho‐anatomical study of clinically silent multiple sclerosis},
  author={Tine Engell},
  journal={Acta Neurologica Scandinavica},
  year={1989},
  volume={79}
}
  • T. Engell
  • Published 1 May 1989
  • Medicine, Psychology
  • Acta Neurologica Scandinavica
ABSTRACT— This is the first study on the frequency, size, number, and location of plaques in clinically silent MS. Among the present 18 patients in whom MS was unexpectedly diagnosed at autopsy, it had been clinically silent in 13. An estimate of the prevalence of silent MS is about 25% of that diagnosed in vivo. In the silent group, the MS plaques were located mainly in the periventricular areas, and this may explain the silent nature of the disease. 
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110 Citations

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References

SHOWING 1-10 OF 10 REFERENCES
Silent brain lesions in patients with isolated idiopathic optic neuritis. A clinical and nuclear magnetic resonance imaging study.
TLDR
Eight of 16 patients with isolated idiopathic optic neuritis were found to have one to several brain lesions by nuclear magnetic resonance scanning, which may be the only manifestation of a multicentric disease process that is disseminated in the central nervous system in the majority of cases.
A clinico‐pathoanatomical study of multiple sclerosis diagnosis
  • T. Engell
  • Medicine, Psychology
    Acta neurologica Scandinavica
  • 1988
TLDR
Neuropathological examination of 518 consecutive patients with clinically definite MS revealed a correct diagnosis in 485 cases (94%).
Unsuspected multiple sclerosis.
Five patients known to have various medical problems were found unexpectedly at autopsy to have typical multiple sclerosis plaques. These were most often small and in a periventricular distribution…
Forms of benign multiple sclerosis. Report of two "clinically silent" cases discovered at autopsy.
TLDR
A wide clinical experience with this exceedingly pleomorphic disease strongly suggests that it may on occasion be a mild disorder indeed—mild in its onset, in its pattern of evolution, or in its ultimate results.
[Demyelination diseases].
INCIDENCE OF INFARCTS OF THE BRAIN IN HEART DISEASES.
Silent brain lesions in patients with isolated optic neuritis
  • Arch Neurol
  • 1986
Lyon-Caen 0. Les sclerosis en plaques asymptomatiques
  • Rev Neurol
  • 1981
Les sclerosis en plaques asymptomatiques
  • Rev Neurol
  • 1981
A clinico - pathoanatomical study of the diagnosis multiple sclerosis
  • Acta Neurol Scand
  • 1988