A clinical model of genetic influences in alcohol dependence.

  title={A clinical model of genetic influences in alcohol dependence.},
  author={Marc A Schuckit},
  journal={Journal of studies on alcohol},
  volume={55 1},
This essay presents a clinical model of the role of genetic factors in alcohol dependence. Data supporting a strong impact of environmental influences along with genetic heterogeneity and the absence of simple Mendelian models combine to produce a complex situation. In light of these complications, this essay presents a model developed by the author's research group focusing on the decreased reaction to alcohol as an important risk factor. The biological contributors might be polygenic or… CONTINUE READING