A clinical evaluation of pyridostigmin bromide in the reversal of curarization

@article{Gotta1970ACE,
  title={A clinical evaluation of pyridostigmin bromide in the reversal of curarization},
  author={Alexander W. Gotta and Colleen A. Sullivan},
  journal={Canadian Anaesthetists’ Society Journal},
  year={1970},
  volume={17},
  pages={527-534}
}
  • A. Gotta, C. Sullivan
  • Published 1 September 1970
  • Medicine
  • Canadian Anaesthetists’ Society Journal
SummaryPyridostigmin bromide in doses of 10 to 20 mg is an effective antagonist of d-tubocurarine when used in the presence of cyclopropane, diethyl ether, methoxyflurane, nitrous oxide, or halothane. When it is used without concurrent atropine, heavy pharyngeal and tracheal secretions are often found, and vagomimetic cardiac arrhythmias are not uncommon. Protection against secretions and vagal arrhythmias can be obtained only with the simultaneous use of 1.0 mg of atropine sulfate. But, at… 
Comparison of atropine and glycopyrrolate in a mixture with pyridostigmine for the antagonism of neuromuscular block.
TLDR
Atropine was associated with a greater initial tachycardia than was glycopyrrolate, and the subsequent bradycardia was also greater in this group, although the decreases in heart rate were smaller than those generally observed following mixtures of atropine and neostigmine.
Potentiation of pyridostigmine bromide toxicity in mice by selected adrenergic agents and caffeine.
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Toxic interactions between Pyridostigmine bromide, several commonly used classes of adrenergic agents and caffeine when exposure occurs in different combinations are demonstrated to demonstrate a toxic synergism.
Influence of anticholinesterase on distribution of ventilation and gas exchange
  • H. Modell
  • Biology, Medicine
    Pharmacology Biochemistry and Behavior
  • 1991

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