A clinical criterion to exclude the hyperimmunoglobulin D syndrome (mild mevalonate kinase deficiency) in patients with recurrent fever.


OBJECTIVE The hyperimmunoglobulin D syndrome (HIDS) is an autosomal recessive autoinflammatory disease caused by mutations in the mevalonate kinase gene. Our objective was to define a clinical criterion able to exclude HIDS without the need of genetic testing. METHODS A recursive partitioning algorithm was applied to derive the clinical criterion in 149… (More)
DOI: 10.3899/jrheum.081313