A clinical correlation of anti-DNA-AGE autoantibodies in type 2 diabetes mellitus with disease duration.

@article{Ashraf2015ACC,
  title={A clinical correlation of anti-DNA-AGE autoantibodies in type 2 diabetes mellitus with disease duration.},
  author={Jalaluddin Mohammad Ashraf and Mir Yasir Arfat and Zarina Arif and Jamal Ahmad and Moinuddin and Khursheed Alam},
  journal={Cellular immunology},
  year={2015},
  volume={293 2},
  pages={
          74-9
        }
}
Nonenzymatic glycation of amino groups of DNA bases by reducing sugars can generate advanced glycation end products (AGEs). Cellular formation of AGEs under normal physiology is continuously scanned and removed by efficient system in the cells. However, excess formation and accumulation of AGEs may be cause or consequence of some human diseases. Mammalian DNA incubated with d-glucose for 28 days at 37°C showed structural changes in DNA as confirmed by UV, fluorescence, CD, melting temperature… CONTINUE READING
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