A clinical classification and grading system of the cutaneous changes in onchocerciasis

@article{Murdoch1993ACC,
  title={A clinical classification and grading system of the cutaneous changes in onchocerciasis},
  author={M. Murdoch and R. Hay and C. Mackenzie and J. F. Williams and H. Ghalib and S. Cousens and A. Abiose and B. Jones},
  journal={British Journal of Dermatology},
  year={1993},
  volume={129}
}
Although onchocerciasis is one of the most important diseases of the skin and eye in the tropical world, to date there has been no formal consensus regarding the description and terminology of skin lesions. Furthermore, the contribution of cutaneous pathology to the morbidity and socio‐economic effects of the disease has been largely neglected. We present a clinical classification and grading system for recording the cutaneous changes of onchocerciasis, and propose that this system be used as a… Expand
Onchodermal skin disease in a hyperendemic onchocerciasis focus in western Uganda.
TLDR
The study concludes that onchodermatitis is a serious medical condition in Kigoyera Parish and needs to be considered in all efforts to control onchocerciasis. Expand
A Rare Case of Cutaneous Onchocerciasis in North-East India, Review of Literature
TLDR
A rare case of cutaneous Onchocerciasis from a non endemic area of North-East India is reported and live adult worms were extracted from the subcutaneous lesions and also micro filariae from the skin nips. Expand
Onchocerciasis: the burden of disease
TLDR
It seems possible, however, that use of Mectizan will eliminate the disease before its true burden can be estimated accurately, and this has enabled mass treatment with MECTizan (ivermectin, MSD) to be targeted first at hyperendemic communities. Expand
Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria
TLDR
Significant levels of onchocercal skin disease were documented in this savanna area, which subsequently resulted in a reassessment of the true burden of skin disease in onchchocerciasis, which may be considered as a composite index of the overall prevalence of on chocercale skin disease. Expand
Onchocerciasis in Anambra State, Southeast Nigeria: endemicity and clinical manifestations
TLDR
Generally low prevalence in the population and absence of symptoms among the youngest age group emphasise the success of the intervention, but the persistent occurrence of acute disease may suggest a shortfall due to low coverage or non-compliance with the mass chemotherapeutic regimen. Expand
Clinical and parasitological aspects of onchocercal skin diseases in Nigeria
An assessment of onchocercal skin disease (OSD) conducted in 38 rural communities in the Imo River Basin, Nigeria, between March 1999 and September 2000, showed that depigmentation (DPM) was the mostExpand
Filariasis: diagnosis and treatment
Filariasis is an infectious disease of the lymphatics and subcutaneous tissues caused by nematodes or filariae. Carried by mosquito vectors, this disease causes millions of people to suffer fromExpand
Onchocerciasis: A review of a filarial disease of significant importance for dermatologists and
TLDR
A review of this troublesome filarial disease with emphasis of its clinical spectrum so that dermatologists, ophthalmologists and physicians in Asia would be able to keep this disease in mind as a differential diagnosis of some unusual case of dermatitis, blindness or arthritis etc. Expand
Mapping the burden of onchocercal skin disease *
  • M. Murdoch
  • Medicine
  • The British journal of dermatology
  • 2020
Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast‐flowing rivers. In humans,Expand
Dermatological manifestations in onchocerciasis: A retrospective study of 400 imported cases.
TLDR
The results indicate the fact that there should be a clinical suspicion of onchocerciasis regarding immigrants from endemic areas having skin lesions compatible with the disease's profile or asymptomatic patients having eosinophilia or unexplained high IgE. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Onchodermatitis—correlation between skin disease and parasitic load in an endemic focus in Ecuador
TLDR
The Amerindians in the endemic onchocerciasis area were more likely than Negroes to have generalized atrophic atrophic changes of the skin, whereas in the latter group significant numbers of individuals had no obvious skin lesions but large numbers of microfilariae were detected in skin snips. Expand
Severe onchocercal dermatitis in the Ethiopian border region of Sudan.
TLDR
The prevalence values of O. volvulus infection in the two villages were significantly increased when, in addition to microfilarial presence in skin biopsies, onchocercal signs such as punctate keratitis, nodule presence andmicrofilariae in the anterior chamber were taken into consideration. Expand
Morphology of posterior segment lesions of the eye in patients with onchocerciasis.
TLDR
The heterogeneity of single lesions, and the occurrence of different types of lesion in a single eye or two eyes, prevented subdivision of the disease into distinct forms and suggested that inflammation alone was responsible for fundus lesions in onchocerciasis. Expand
Babana Parasitic Diseases Project. I. The study area and a preliminary assessment of onchocercal endemicity based on the prevalence of "leopard skin".
TLDR
The findings suggested that onchocerciasis is highly endemic in this community, and LS occurred more frequently among the cattle Fulani people than among other local ethnic groups. Expand
Onchocerciasis Presenting Without Dermatitis
TLDR
Clinical or biochemical evidence of porphyria has usually followed the diagnosis of the diabetes by several years, but has occasionally preceded it, and there would seem to be no evidence that the conditions are genetically linked. Expand
Variation in delayed hypersensitivity in onchocerciasis.
TLDR
In this study, soluble antigen preparations were made from Onchocerca volvulus adults recovered from subcutaneous nodules, and from Necator americanus third-stage larvae, and reactions to N. americanus antigen, both immediate and delayed, were seen in both forms of the disease. Expand
Some observations on onchocerciasis including sowda in the Yemen Arab Republic.
TLDR
A pilot study on onchocerciasis and sowda was carried out in the south-western region of the Yemen Arab Republic and no morphological differences could be detected between the smaller number of the examined worms and the extensive parasite material from Liberia, West Africa. Expand
Variations in host responses and the pathogenesis of human onchocerciasis.
TLDR
A quantitative system dividing symptoms into those associated with active responses to the microfilariae and those representing long-term consequences of these reactions is suggested, indicating that the level of O. volvulus-specific immune complexes is inversely proportional to theMicrofilarial load. Expand
Studies on onchocerciasis in the United Cameroon Republic. I. Comparison of populations with and without Onchocerca volvulus.
TLDR
The results of an onchocerciasis survey of total populations aged 5 years and over in 22 village groups in Cameroon rain-forest and savanna are reported and skin and eye lesions in 2,678 persons infected with O. volvulus are compared with lesions in 1,156 persons in whom the parasite was not detected. Expand
(36) Mixed features of bullous ichthyosiform erythroderma and ichthyosis bullosa of Siemens
TLDR
This patient's skin condition has understandably caused much suffering and disability throughout his life, and it is unusual for patients with severe NBIE to survive to this age. Expand
...
1
2
3
4
...