A clinical appraisal of the genetic basis in unexplained male infertility

  title={A clinical appraisal of the genetic basis in unexplained male infertility},
  author={Sandro C. Esteves},
  booktitle={Journal of human reproductive sciences},
Unexplained male infertility (UMI), the inability to reproduce despite having a normal sexual history, physical exam and semen analysis, can have a genetic origin. Currently, few diagnostic tools are available for detecting such genetic abnormalities. Karyotyping and fluorescence in situ hybridization (FISH) are respectively used for chromosomal alterations in somatic cells and sperm aneuploidy assessment. Gene sequencing and mutational analysis have been introduced for identifying specific… CONTINUE READING
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