A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery.

@article{OMahony2012ACC,
  title={A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery.},
  author={Aoife M O'Mahony and Julien R Ogier and St{\'e}phane Desgranges and John F Cryan and Raphael Darcy and Caitriona M O'driscoll},
  journal={Organic & biomolecular chemistry},
  year={2012},
  volume={10 25},
  pages={4954-60}
}
A new approach to the synthesis of amphiphilic β-cyclodextrins has used 'click' chemistry to selectively modify the secondary 2-hydroxyl group. The resulting extended polar groups can be either polycationic or neutral PEGylated groups and these two amphiphile classes are compatible in dual cyclodextrin formulations for delivery of siRNA. When used alone with an siRNA, a cationic cyclodextrin was shown to have good transfection properties in cell culture. Co-formulation with a PEGylated… CONTINUE READING

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