A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.

@article{Tachikawa2012ACS,
  title={A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.},
  author={Masanori Tachikawa and Kazuhiro Tsuji and Reiji Yokoyama and Takanori Higuchi and Go Ozeki and Ayane Yashiki and Shin-ichi Akanuma and Kazuyuki Hayashi and Akio Nishiura and Ken-Ichi Hosoya},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2012},
  volume={343 3},
  pages={608-16}
}
Although the level of prostaglandin (PG) D(2) in cerebrospinal fluid (CSF) affects the action of D-type prostanoid receptors that promote physiological sleep, the regulatory system of PGD(2) clearance from the CSF is not fully understood. The purpose of this study was to investigate PGD(2) elimination from the CSF via the blood-CSF barrier (BCSFB). The in… CONTINUE READING