A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.

@article{Raynaud2011ACO,
  title={A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.},
  author={Peggy Raynaud and Joshua C. Tate and C{\'e}line Callens and Sabine Cordi and Patrick Vandersmissen and Rodolphe Carpentier and Christine Sempoux and Olivier Devuyst and Christophe E Pierreux and Pierre J. Courtoy and Karin Dahan and Katty Delbecque and S{\'e}bastien Lepreux and Marco Pontoglio and L. M. Guay-Woodford and F. P. Lemaigre},
  journal={Hepatology},
  year={2011},
  volume={53 6},
  pages={1959-66}
}
UNLABELLED Ductal plate malformations (DPMs) are developmental anomalies considered to result from lack of ductal plate remodeling during bile duct morphogenesis. In mice, bile duct development is initiated by the formation of primitive ductal structures lined by two cell types, namely ductal plate cells and hepatoblasts. During ductal plate remodeling, the primitive ductal structures mature to ducts as a result from differentiation of the ductal plate cells and hepatoblasts to cholangiocytes… CONTINUE READING

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