A classification framework and practical guidance for establishing a mode of action for chemical carcinogens.

@article{Butterworth2006ACF,
  title={A classification framework and practical guidance for establishing a mode of action for chemical carcinogens.},
  author={Byron E. Butterworth},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2006},
  volume={45 1},
  pages={9-23}
}
The recently released U.S. Environmental Protection Agency (U.S. EPA) Supplemental Guidance for Assessing Risk from Early Life Exposure to Carcinogens (SGAC) provides guidance to account for potential increased early life susceptibility to carcinogens that are acting via a mutagenic mode of action. While determination of the mode of carcinogenic action is central to the SGAC procedures and other regulatory risk assessments, little guidance is given as to the approaches, criteria, and nature of… CONTINUE READING