A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide

  title={A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide},
  author={Nour Sayed and Ambre Jousselin and Brice Felden},
  journal={Nature Structural \&Molecular Biology},
Antisense RNAs (asRNAs) pair to RNAs expressed from the complementary strand, and their functions are thought to depend on nucleotide overlap with genes on the opposite strand. There is little information on the roles and mechanisms of asRNAs. We show that a cis asRNA acts in trans, using a domain outside its target complementary sequence. SprA1 small regulatory RNA (sRNA) and SprA1AS asRNA are concomitantly expressed in S. aureus. SprA1AS forms a complex with SprA1, preventing translation of… 

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Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains.

  • C. PichonB. Felden
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
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Regulatory RNAs in Bacteria

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