A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.

@article{Yates1984ACE,
  title={A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.},
  author={John Yates and Noreen Warren and D J Reisman and Bill Sugden},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 12},
  pages={3806-10}
}
The Epstein-Barr viral (EBV) genome of approximately equal to 170 kilobase pairs (kbp) is maintained as a plasmid in human B lymphoblasts transformed by the virus. We have identified a cis-acting element within 1.8 kbp of the viral genome that allows recombinant plasmids carrying it to be selected at high frequency and maintained as plasmids in cells latently infected by EBV. This functional element(s) requires a segment of DNA at least 800 bp and at most 1800 bp long, which contains a family… CONTINUE READING

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