A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.

@article{Feng2011ACR,
  title={A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.},
  author={Dan Feng and Tao Liu and Zheng Sun and Anne Bugge and Shannon E. Mullican and Theresa Alenghat and Xiaole Shirley Liu and Mitchell A Lazar},
  journal={Science},
  year={2011},
  volume={331 6022},
  pages={1315-9}
}
Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbα. Rev-erbα colocalizes with… CONTINUE READING
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