A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.

@article{Williams2001ACO,
  title={A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.},
  author={J. Andrew Williams and Henry S. Su and Andre Bernards and Jeremy Field and Amita Sehgal},
  journal={Science},
  year={2001},
  volume={293 5538},
  pages={2251-6}
}
Output from the circadian clock controls rhythmic behavior through poorly understood mechanisms. In Drosophila, null mutations of the neurofibromatosis-1 (Nf1) gene produce abnormalities of circadian rhythms in locomotor activity. Mutant flies show normal oscillations of the clock genes period (per) and timeless (tim) and of their corresponding proteins, but altered oscillations and levels of a clock-controlled reporter. Mitogen-activated protein kinase (MAPK) activity is increased in Nf1… CONTINUE READING

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Mentioned Connections BETA
Neurofibromatosis 1Pathogenesis of disease involves geneNF1 gene
In Drosophila , null mutations of the neurofibromatosis-1 ( Nf1 ) gene produce abnormalities of circadian rhythms in locomotor activity .
In Drosophila , null mutations of the neurofibromatosis-1 ( Nf1 ) gene produce abnormalities of circadian rhythms in locomotor activity .
NF1 geneGene mapped to diseaseNeurofibromatosis 1
In Drosophila , null mutations of the neurofibromatosis-1 ( Nf1 ) gene produce abnormalities of circadian rhythms in locomotor activity .
In Drosophila , null mutations of the neurofibromatosis-1 ( Nf1 ) gene produce abnormalities of circadian rhythms in locomotor activity .
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