A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.

@article{Williams2001ACO,
  title={A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.},
  author={Jim A. Williams and Henry S. Su and Andre Bernards and J. Timothy Field and Amita Sehgal},
  journal={Science},
  year={2001},
  volume={293 5538},
  pages={2251-6}
}
Output from the circadian clock controls rhythmic behavior through poorly understood mechanisms. In Drosophila, null mutations of the neurofibromatosis-1 (Nf1) gene produce abnormalities of circadian rhythms in locomotor activity. Mutant flies show normal oscillations of the clock genes period (per) and timeless (tim) and of their corresponding proteins, but altered oscillations and levels of a clock-controlled reporter. Mitogen-activated protein kinase (MAPK) activity is increased in Nf1… CONTINUE READING

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