A chymotryptic-type serine protease is required for IL-2 production by Jurkat T cells.

@article{Auberger1990ACS,
  title={A chymotryptic-type serine protease is required for IL-2 production by Jurkat T cells.},
  author={Patrick Auberger and S Sonthonnax and Jean François Peyron and Bernard Mari and Max Fehlmann},
  journal={Immunology},
  year={1990},
  volume={70 4},
  pages={
          547-50
        }
}
Interleukin-2 (IL-2) production by activated Jurkat T cells was markedly delayed when these cells were treated with low concentrations of the chymotryptic-type protease inhibitor N-alpha-p-tosyl-L-phenylalanine chloromethylketone (TPCK). This increased lag time observed in the presence of TPCK directly correlates with the interaction of the inhibitor with a unique 42,000 molecular weight (MW) serine protease, which can be labelled with [3H]DFP, and was not due to an intracellular accumulation… CONTINUE READING