A chymotrypsin-type serine protease in rat basophilic leukemia cells: evidence for its immunologic identity with atypical mast cell protease.

@article{Kido1986ACS,
  title={A chymotrypsin-type serine protease in rat basophilic leukemia cells: evidence for its immunologic identity with atypical mast cell protease.},
  author={Hiroshi Kido and Keisuke Izumi and Hisashi Otsuka and Naomi Fukusen and Yasuhisa Kato and Nobuhiko Katunuma},
  journal={Journal of immunology},
  year={1986},
  volume={136 3},
  pages={1061-5}
}
Activity of a chymotrypsin-type serine protease was found in a subline of rat basophilic leukemia (RBL-2H3) cells. The protease was immunologically cross-reactive with anti-atypical mast cell protease immunoglobulin (Ig) G, and its activity was inhibited in a dose-dependent manner by the antibody. The apparent m.w. of the protease that reacted with the antibody was 25,000, which was identical with that of atypical mast cell protease in rat mucosal mast cells. These results show that the… CONTINUE READING