A chronocoulometric LNA sensor for amplified detection of K-ras mutation based on site-specific DNA cleavage of restriction endonuclease.

@article{Lin2013ACL,
  title={A chronocoulometric LNA sensor for amplified detection of K-ras mutation based on site-specific DNA cleavage of restriction endonuclease.},
  author={Liqing Lin and Ailin Liu and Chengfei Zhao and Shaohuang Weng and Yun Lei and Qicai Liu and Xinhua Lin and Yuan-Zhong Chen},
  journal={Biosensors & bioelectronics},
  year={2013},
  volume={42},
  pages={409-14}
}
An amplified chronocoulometric Locked nucleic acid (LNA) sensor (CLS) for selective electrochemical detection of K-ras mutation was developed based on site-specific DNA cleavage of restriction endonuclease EcoRI. Thiolated-hairpin LNA probe with palindrome structure of stem was immobilized on the gold nanoparticles modified gold electrode (NG/AuE). It can… CONTINUE READING