A chronic toxicity study of josamycin in F344 rats.

@article{Kasahara2002ACT,
  title={A chronic toxicity study of josamycin in F344 rats.},
  author={K. Kasahara and A. Nishikawa and F. Furukawa and S. Ikezaki and Z. Tanakamaru and I.-S. Lee and T. Imazawa and M. Hirose},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2002},
  volume={40 7},
  pages={
          1017-22
        }
}
  • K. Kasahara, A. Nishikawa, +5 authors M. Hirose
  • Published 2002
  • Medicine, Chemistry
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
The chronic toxicity of josamycin was examined in Fischer 344 (F344) rats. Groups of 10 males and 10 females were given the test compound in the diet at concentrations of 0 (control), 0.02, 0.1, 0.5 or 2.5% for 52 weeks. Daily intake of josamycin was 0, 10, 50, 260 and 1310 mg/kg body weight in males and 0, 10, 60, 290 and 1460 mg/kg body weight in females, respectively. Body weight gain was significantly (P<0.05) reduced in the male 2.5% group but no noticeable changes were found in food… Expand
2 Citations

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