A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.

@article{Glynn2008ACI,
  title={A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.},
  author={Erin L. Glynn and Heidi L. Lujan and Victoria J Kramer and Micah J Drummond and Stephen E DiCarlo and Blake B Rasmussen},
  journal={Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme},
  year={2008},
  volume={33 1},
  pages={93-101}
}
A chronic increase in physical activity and (or) endurance training can improve insulin sensitivity in insulin-resistant skeletal muscle. Cellular mechanisms responsible for the development of insulin resistance are unclear, though one proposed mechanism is that nutrient overload chronically increases available energy, over-activating the mammalian target of rapamycin (mTOR) and ribosomal S6 kinase 1 (S6K1) signaling pathway leading to increased phosphorylation of serine residues on insulin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

mTOR function in skeletal muscle: a focal point for overnutrition and exercise.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme • 2009
View 1 Excerpt
Highly Influenced

Koschei the immortal and anti-aging drugs

Cell Death and Disease • 2014
View 1 Excerpt

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

Diabetes & metabolism journal • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…