A chronic in vivo liver perfusion technique in ruminants.


A model for chronic perfusion of the liver of ruminants was developed. This allowed for investigation of the pathophysiology of pyrrolizidine alkaloids (PA) in two species. This model has general application to toxicological studies for both acute or chronic perfusion, as well as, metabolic studies utilizing sheep, cattle or goats. Catheterization of the… (More)


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