A chronic high fat diet alters the homologous and heterologous control of appetite regulating peptide receptor expression

@article{Kentish2013ACH,
  title={A chronic high fat diet alters the homologous and heterologous control of appetite regulating peptide receptor expression},
  author={Stephen J. Kentish and Gary A Wittert and L Ashley Blackshaw and Amanda J. Page},
  journal={Peptides},
  year={2013},
  volume={46},
  pages={150-158}
}
Leptin, ghrelin and neuropeptide W (NPW) modulate vagal afferent activity, which may underlie their appetite regulatory actions. High fat diet (HFD)-induced obesity induces changes in the plasma levels of these peptides and alters the expression of receptors on vagal afferents. We investigated homologous and heterologous receptor regulation by leptin, ghrelin and NPW. Mice were fed (12 weeks) a standard laboratory diet (SLD) or HFD. Nodose ganglia were cultured overnight in the presence or… CONTINUE READING
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