A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey.

@article{Bzard1997ACM,
  title={A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey.},
  author={Erwan B{\'e}zard and Christine Imbert and X Deloire and Bernard H Bioulac and Christian Eric Gross},
  journal={Brain research},
  year={1997},
  volume={766 1-2},
  pages={107-12}
}
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to induce parkinsonism both in man and non-human primates. Several models have now been developed, but acute MPTP administration does not consistently reproduce all the clinical features of the disease. To mirror the slow evolution observed in human pathology, a chronic model of intoxication is necessary. The present study describes a chronic MPTP protocol in the monkey. Six monkeys received daily injections of MPTP (0.2 mg/kg i… CONTINUE READING