A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.

@article{Sadaie2004ACP,
  title={A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.},
  author={Mahito Sadaie and Tetsushi Iida and Takeshi Urano and Jun-ichi Nakayama},
  journal={The EMBO journal},
  year={2004},
  volume={23 19},
  pages={3825-35}
}
The chromodomain is a conserved motif that functions in the epigenetic control of gene expression. Here, we report the functional characterization of a chromodomain protein, Chp1, in the heterochromatin assembly in fission yeast. We show that Chp1 is a structural component of three heterochromatic regions-centromeres, the mating-type region, and telomeres-and that its localization in these regions is dependent on the histone methyltransferase Clr4. Although deletion of the chp1(+) gene causes… CONTINUE READING
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