A chromatin remodelling complex that loads cohesin onto human chromosomes

  title={A chromatin remodelling complex that loads cohesin onto human chromosomes},
  author={Mohamed-Ali Hakimi and Daniel A. Bochar and John A. Schmiesing and Yuanshu Dong and Orr G. Barak and David W. Speicher and Kyoko Yokomori and Ramin Shiekhattar},
Nucleosomal DNA is arranged in a higher-order structure that presents a barrier to most cellular processes involving protein DNA interactions. The cellular machinery involved in sister chromatid cohesion, the cohesin complex, also requires access to the nucleosomal DNA to perform its function in chromosome segregation. The machineries that provide this accessibility are termed chromatin remodelling factors. Here, we report the isolation of a human ISWI (SNF2h)-containing chromatin remodelling… CONTINUE READING
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