A chromatin-remodeling protein is a component of fission yeast mediator.

@article{Khorosjutina2010ACP,
  title={A chromatin-remodeling protein is a component of fission yeast mediator.},
  author={Olga Khorosjutina and Paulina H Wanrooij and Julian Walfridsson and Zsolt Szil{\'a}gyi and Xuefeng Zhu and Vera Baraznenok and Karl Ekwall and Claes M. Gustafsson},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 39},
  pages={29729-37}
}
The multiprotein Mediator complex is an important regulator of RNA polymerase II-dependent genes in eukaryotic cells. In contrast to the situation in many other eukaryotes, the conserved Med15 protein is not a stable component of Mediator isolated from fission yeast. We here demonstrate that Med15 exists in a protein complex together with Hrp1, a CHD1 ATP-dependent chromatin-remodeling protein. The Med15-Hrp1 subcomplex is not a component of the core Mediator complex but can interact with the L… CONTINUE READING