A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma.

@article{Boeuf2008ACG,
  title={A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma.},
  author={St{\'e}phane Boeuf and Pierre Kunz and Tilla Hennig and Ben Lehner and Pcw Hogendoorn and Jvmg Bov{\'e}e and Wiltrud Richter},
  journal={The Journal of pathology},
  year={2008},
  volume={216 2},
  pages={158-66}
}
Phenotypic and molecular parallels between the development of chondrosarcoma and the differentiation of chondrocytes in normal growth plate suggest that chondrosarcoma may arise from mesenchymal precursor cells driven towards chondrogenesis. We hypothesized that a comparison between cartilaginous tumours and their possible physiological cells of origin, mesenchymal stem cells (MSCs), might have biological and clinical relevance. MSCs from eight donors were submitted to chondrogenic… CONTINUE READING
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