A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

@inproceedings{Carnevale2016ACP,
  title={A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication},
  author={Daniela Carnevale and Marialuisa Perrotta and Fabio Pallante and Valentina Fardella and Roberta Iacobucci and Stefania Fardella and Lorenzo Carnevale and Raimondo Carnevale and Massimiliano De Lucia and Giuseppe Cifelli and Giuseppe Lembo},
  booktitle={Nature communications},
  year={2016}
}
The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connection are unknown. Here, we show that hypertensive challenges activate splenic sympathetic nerve discharge to prime immune response. More specifically, a vagus-splenic nerve drive, mediated by nicotinic cholinergic receptors, links the brain and… CONTINUE READING
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