A cholinergic input to the substantia nigra pars compacta increases striatal dopamine metabolism measured by in vivo voltammetry.

@article{HernndezLpez1992ACI,
  title={A cholinergic input to the substantia nigra pars compacta increases striatal dopamine metabolism measured by in vivo voltammetry.},
  author={Salvador Hern{\'a}ndez-L{\'o}pez and Jos{\'e} Luis G{\'o}ngora-Alfaro and Elizabeth Garc{\'i}a-Garc{\'i}a and Jorge Guti{\'e}rrez Aceves},
  journal={Brain research},
  year={1992},
  volume={598 1-2},
  pages={114-20}
}
3,4-Dihydroxyphenylacetic acid (DOPAC) and ascorbic acid (AA) were measured by differential pulse voltammetry in the neostriatum of anesthetized rats. Physostigmine (2.3 nmol) applied into the substantia nigra pars compacta (SNc), increased DOPAC concentration in the ipsilateral neostriatum, but did not modify AA levels. The largest increase of striatal DOPAC (37 +/- 8% above basal) was observed when physostigmine was applied at less than 0.5 mm from SNc, and decreased with increasing distance… CONTINUE READING
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