A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin.

@article{Cano2008ACR,
  title={A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin.},
  author={V Cano and Beatriz Merino and Laura Ezquerra and Beatriz Somoza and Mariano Ruiz-Gayo},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 5},
  pages={1009-15}
}
BACKGROUND AND PURPOSE Leptin regulates energy expenditure and body weight by acting both on the hypothalamus and on peripheral targets. Central actions of leptin are enhanced by cholecystokinin (CCK). The interaction between leptin and CCK makes physiological sense, as rats lacking CCK1 receptors are resistant to peripheral leptin but not to leptin directly infused into the brain. We have recently reported that CCK enhances leptin effects by increasing the entry of leptin into the CNS. The aim… CONTINUE READING

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