A chitosan-graft-PEI-candesartan conjugate for targeted co-delivery of drug and gene in anti-angiogenesis cancer therapy.

@article{Bao2014ACC,
  title={A chitosan-graft-PEI-candesartan conjugate for targeted co-delivery of drug and gene in anti-angiogenesis cancer therapy.},
  author={Xiuli Bao and Wei Wang and Cheng Wang and Yu Wang and Jianping Zhou and Yang Ding and Xiaoyi Wang and Yuting Jin},
  journal={Biomaterials},
  year={2014},
  volume={35 29},
  pages={
          8450-66
        }
}
A multifunctional copolymer-anticancer conjugate chitosan-graft-polyethyleneimine-candesartan (CPC) containing low molecular weight chitosan (CS) backbone and polyethyleneimine (PEI) arms with candesartan (CD) conjugated via an amide bond was fabricated as a targeted co-delivery nanovector of drug and gene for potential cancer therapy. Here, CD was utilized to specifically bind to overexpressed angiotensin II type 1 receptor (AT1R) of tumor cells, strengthen endosomal buffering capacity of CPC… CONTINUE READING
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References

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Showing 1-10 of 50 references

Linear PEI nanoparticles: efficient pDNA/siRNA carriers in vitro and in vivo.

Nanomedicine : nanotechnology, biology, and medicine • 2012
View 1 Excerpt