A chirality index for investigating protein secondary structures and their time evolution

@article{Pietropaolo2008ACI,
  title={A chirality index for investigating protein secondary structures and their time evolution},
  author={Adriana Pietropaolo and Luca Muccioli and Roberto Berardi and Claudio Zannoni},
  journal={Proteins: Structure},
  year={2008},
  volume={70}
}
We propose a methodology for the description of the secondary structure of proteins, based on assigning a chirality parameter to short aminoacid sequences according to their arrangement in space at a certain time. We validated the method on ideal and crystalline structures, showing that it can assign secondary structures and that this assignment is robust with respect to random conformational perturbations. From the values of the index and its pattern along a sequence it is possible to… 
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30 Citations
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Methods Citations
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30 Citations

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Citation Type

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TLDR
By analyzing selected structures of DNA and RNA, it is found that sequences rich in cytosine and guanine have a tendency to left-handed chirality, in contrast to regions rich in adenine or thymine which show strong negative, right-handed, chiralities values.
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How unsupervised machine learning schemes can be used to recognize patterns based exclusively on the frequency with which different motifs occur is discussed, taking high-resolution structures from the Protein Data Bank as benchmarks.
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TLDR
It is shown that the occurrence of the conformations of the macromolecular polypeptide backbone is related to the value of the CI of the constituting peptide fragments, and how the CI can be used to assess the quality of a crystallographic electron density map.
Similarity and Chirality Measures for Liquid Crystal
The mechanism for the transfer of chirality between a chiral dopant and an achiral liquid crystal host phase remains the subject of conjecture. A review of the theoretical approaches undertaken to…
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TLDR
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