A chimeric ribozyme in clostridium difficile combines features of group I introns and insertion elements.

@article{Braun2000ACR,
  title={A chimeric ribozyme in clostridium difficile combines features of group I introns and insertion elements.},
  author={Volkmar Braun and M Mehlig and Michael Moos and Maja Rupnik and Bettina Kalt and David. E. Mahony and Christoph von Eichel-Streiber},
  journal={Molecular microbiology},
  year={2000},
  volume={36 6},
  pages={1447-59}
}
CdlSt1, a DNA insertion of 1975 bp, was identified within tcdA-C34, the enterotoxin gene of the Clostridium difficile isolate C34. Located in the catalytic domain A1-C34, Cd/St1 combines features of two genetic elements. Within the first 434 nt structures characteristic for group I introns were found; encoding the two transposase-like proteins tlpA and tlpB nucleotides 435-1975 represent the remainder of a IS605-like insertion element. We show that the entire CdlSt1 is accurately spliced from… CONTINUE READING
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