A chimeric protein that functions as both an anthrax dual-target antitoxin and a trivalent vaccine.

@article{Wu2010ACP,
  title={A chimeric protein that functions as both an anthrax dual-target antitoxin and a trivalent vaccine.},
  author={Gaobing Wu and Yuzhi Hong and Aizhen Guo and Chunfang Feng and Sha Cao and Cheng-Cai Zhang and Ruiping Shi and Yadi Tan and Ziduo Liu},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 11},
  pages={
          4750-7
        }
}
Effective measures for the prophylaxis and treatment of anthrax are still required for counteracting the threat posed by inhalation anthrax. In this study, we first demonstrated that the chimeric protein LFn-PA, created by fusing the protective antigen (PA)-binding domain of lethal factor (LFn) to PA, retained the functions of the respective molecules. On the basis of this observation, we attempted to develop an antitoxin that targets the binding of lethal factor (LF) and/or edema factor (EF… CONTINUE READING
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