A chimeric human T-cell lymphotropic virus type 1 with the envelope glycoprotein of Moloney murine leukemia virus is infectious for murine cells.

@article{Delebecque2002ACH,
  title={A chimeric human T-cell lymphotropic virus type 1 with the envelope glycoprotein of Moloney murine leukemia virus is infectious for murine cells.},
  author={Fr{\'e}d{\'e}ric Delebecque and Karin Pramberger and Marie-Christine Pr{\'e}vost and Michel Brahic and Fr{\'e}d{\'e}ric Tangy},
  journal={Journal of virology},
  year={2002},
  volume={76 15},
  pages={7883-9}
}
We constructed a chimeric human T-cell lymphotropic virus type 1 (HTLV-1) provirus in which the original envelope precursor sequence was replaced by that of ecotropic Moloney murine leukemia virus (Mo-MuLV). Chimeric particles produced by transient transfection of this chimeric provirus were infectious for murine cells, such as NIH 3T3 fibroblasts, lymphoid EL4 cells, and primary CD4(+) T lymphocytes, whereas HTLV-1 particles were not. The infectivity of chimeric particles increased 10 times… CONTINUE READING
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HTLV-I infection in squirrel monkeys (Saïmiri sciureus) using autologous, homologous or heterologous HTLV-Iproducing cell lines

  • M. Kazanji, J. P. Moreau, +4 authors G. De Thé
  • Virology
  • 1997
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