A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction.

Abstract

Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine deficiency. We report a child with valproic acid-associated carnitine deficiency who had severe cardiac dysfunction develop that resolved with carnitine replacement therapy.

Statistics

0100200300'96'98'00'02'04'06'08'10'12'14'16
Citations per Year

109 Citations

Semantic Scholar estimates that this publication has 109 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Bratton1992ACW, title={A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction.}, author={Susan L. Bratton and Anna L Garden and Timothy P. Bohan and J. W. French and Wil Clarke}, journal={Journal of child neurology}, year={1992}, volume={7 4}, pages={413-6} }