A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.

@article{Massena2010ACG,
  title={A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.},
  author={Sara Massena and Gustaf Christoffersson and Elina Hjertstr{\"o}m and Eyal Zcharia and Israel Vlodavsky and Nora Ausmees and Charlotte Rolny and Jin-Ping Li and Mia Phillipson},
  journal={Blood},
  year={2010},
  volume={116 11},
  pages={1924-31}
}
During infection, chemokines sequestered on endothelium induce recruitment of circulating leukocytes into the tissue where they chemotax along chemokine gradients toward the afflicted site. The aim of this in vivo study was to determine whether a chemokine gradient was formed intravascularly and influenced intraluminal neutrophil crawling and transmigration. A chemokine gradient was induced by placing a macrophage inflammatory protein-2 (MIP-2)-containing (CXCL2) gel on the cremaster muscle of… CONTINUE READING